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Prior weight loss attempts
Clinicians may choose between a one-to-two-week washout before semaglutide initiation (preferred for patients with significant side effects) or a same-day switch, starting semaglutide on the next scheduled tirzepatide dose day
Additionally, inadequate sleep, high stress levels, and certain dietary choices (particularly those high in refined carbohydrates) can influence hunger hormones like ghrelin and leptin
Consistency in supplementation, along with a healthy lifestyle, is key to achieving visible benefits, which usually become noticeable after 8-12 weeks
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